The relationship between levels of von Willebrand factor and mean platelet volume in subjects with isolated impaired fasting glucose

BACKGROUND To understand the heterogeneity of platelets, we investigated the correlation between von Willebrand factor (vWf) and mean platelet volume (MPV) in subjects with isolated impaired fasting glucose (IFG). MATERIAL/METHODS We selected 48 subjects with isolated IFG and 48 normoglycemic control subjects matched for age, sex, and body mass index. We measured levels of vWf and MPV in all subjects. RESULTS The levels of vWf and MPV were significantly higher in the isolated IFG group than the control group (p<0.05) Also, vWf level was positively correlated with MPV level in subjects in the isolated IFG group (r=0.452, p=0.001). CONCLUSIONS Our results suggest that vWf seems to be profoundly related to platelet volume in subjects with isolated IFG.